M. L. Aleksandrov, L. N. Gall, N. V. Krasnov, V. I. Nikolaev, and V. A.
Shkurov.
Mass Spectrometric Analysis of Thermally Unstable Compounds of Low
Volatility by the Extraction of Ions from Solution at Atmospheric Pressure.
Journal of Analytical Chemistry USSR, 40:1227-1236, 1985.
Orginal:Zhurnal Analiticheskoi Khimii (1985), Vol. 40, No. 9,
1570-1580.
Raghuvir K. Arni, Udo Heinemann, Maria K. Maslowska, R. Tokuoka, and Wolfram
Saenger.
Restrained least-squares fitting refinement of the crystal structure
of the ribonuclease T1 * 2'guanylic acid complex at 1.9 angstroms
resolution.
Acta Crystallogr Sect. B, 43:549, 1987.
Raghuvir K. Arni, Leandra Watanabe, Richard J. Ward, Robert J. Kreitman, Kapil
Kumar, and Frederick G. Walz, Jr.
Three-dimensional structure of ribonuclease T complexed with
an isosteric phosphonate substrate analogue of gpu: Alternate substrate
bindung modes and catalysis.
Biochemistry, 38(8):2452-2461, 1999.
Jan Backmann, Carola C. Doray, Hans-Peter Grunert, Olfert Landt, and Ulrich
Hahn.
Extended kinetic analysis of ribonuclease T1 variants leads to an
improved scheme for the reaction mechanism.
Biochemical and Biophysical Research Communications,
199(1):213-219, 2 1994.
Richard M. Caprioli.
Analysis of biochemical reactions with molecular specificity using
fast atom bombardment mass spectrometry.
Biochemistry, 27(2):513-521, 1988.
Thomas R. Covey, Ronald F. Bonner, Bori I. Shushan, and Jack Jenion.
The Determination of Protein, Oligonucleotide and Peptide Molecular
Weights by Ion-spray Mass Spectrometry.
Rapid Communications in Mass Spectrometry, 2(11):249-256,
1988.
Malcolm Dole, L. L. Mack, R. L. Hines, R. C. Mobley, L. D. Ferguson, and M. B.
Alice.
Molecular Beams of Macroions.
Journal of Chemical Physics, 49(5):2240-2249, 1968.
Helen Donis-Keller, Allan M. Maxam, and Walter Gilbert.
Mapping adenines, guanines, and pyrimidines in rna.
Nucleic Acids Research, 4(8):2527-2538, 1977.
Arne Elofsson and Lennart Nilsson.
1.2 ns molecular dynamics simulation of the ribonuclease
t1-3'-guanosine monophosphate complex.
Journal of Physical Chemistry, 100(7):2480-2488, 1996.
Paul N. Epstein, Ramachandra R. Reddy, and Harry Busch.
Site-specific cleavage by t1 rnase of u-1 rna in u-1
ribonucleoprotein particles.
Proceedings of the National Academy of Science USA,
78(3):1562-1566, 1981.
Daniele Fabris and Catherine Fenselau.
Characterization of allosteric insulin hexamers by electrospray
ionization mass spectrometry.
Analytical Chemistry, 71(2):384-387, 1 1999.
Thilo A. Fligge, J Kast, Kai Bruns, and Michael Pryzbylski.
Direct monitoring of protein-chemical reactions utilising
nanoelectrospray mass spectrometry.
Journal of the American Society for Mass Spectrometry,
10(2):112-118, 1999.
Francisco García-Sevilla, Carmelo Garrido-del Solo, Ronald G. Duggleby,
Francisco García-Cánovas, Ramón Peyró, and Ramón
Varón.
Use of a windows program for simulation of the progress curves of
reactants and intermediates involved in enzyme-catalyzed reactions.
Biosystems, 54(3):151-164, 2000.
Joachim Granzin, Ramon Puras-Lutzke, Olfert Landt, Hans-Peter Grunert, Udo
Heinemann, Wolfram Saenger, and Ulrich Hahn.
Rnase t1 mutant glu46gln binds the inhibitors 2'gmp and 2'amp at the
3' subsite.
Journal of Molecular Biology, 225(2):533-543, 1992.
Hans-Peter Grunert, Olfert Landt, Maria Zirpel-Giesebrecht, Jan Backmann, Udo
Heinemann, Wolfram Saenger, and Ulrich Hahn.
Trp59 to Tyr substitution enhances the catalytic activity of
RNase T1 and of the Tyr to Trp variants in positions 24, 42 and 45.
Protein Engineering, 6(7):739-744, 1993.
Toshio Hakoshima, Shoji Toda, Shigetoshi Sugio, Ken ichi Tomita, Satoshi
Nishikawa, Hiroshi Morioka, Kayoko Fuchimura, Tsuyoshi Kimura, Sei ichi
Uesugi, Eiko Ohtsuka, and Morio Kehara.
Conformational properties of the guanine-binding site of
ribonuclease t inferred from x-ray structure and protein engineering.
Protein Engineering, 2(1):55-51, 1988.
John Burdon Sanderson Haldane and K. G. Stern.
Allgemeine chemie der enzyme.
In R. E. Liesegung, editor, Wissenschaftliche
Forschungsberichte, Naturwissenschaftliche, volume 28. Theo. Steinkopf,
Dresden, 1932.
C. S. Hanes.
The effects of starch concentration upon the velocity of hydrolysis
by the amylase of germinated barley.
Biochemical Journal, 26:1406-1421, 1932.
Udo Heinemann and Wolfram Saenger.
Specific protein-nucleic acid recognition in ribonuclease
t1-2'-guanylic acid complex: an x-ray study.
Nature, 299(5878):27-31, 1982.
S. Hirono and Peter A. Kollman.
Relative binding free energy calculations of inhibitors to two
mutants (glu46-ala/gln) of ribonuclease t1 using molecular dynamics/free
energy perturbation approaches.
Protein Engineering, 4(3):233-243, 1991.
Katja Höschler, Helga Hoier, Bernd Hubner, Wolfram Saenger, Peter Orth,
and Ulrich Hahn.
Structural analysis of an rnase t1 variant with an altered guanine
binding segment.
Journal of Molecular Biology, 294(5):1231-1238, 1999.
Bernd Hubner, Marion Haensler, and Ulrich Hahn.
Modification of ribonuclease t1 specificity by random mutagenesis of
the substrate binding segment.
Biochemistry, 38(4):1371-1376, 1999.
Keith R. Jennings and Gregory G. Dolnikowski.
Mass analyzers.
In James A. McCloskey, editor, Methods in Enzymology, volume
193, pages 37-61. Academic Press, Inc, 1990.
Reinhard Juraschek, Thomas Dülcks, and Michael Karas.
Nanoelectrospray--more than just a minimized-flow electrospray ion
source.
Journal of the American Society for Mass Spectrometry,
10:300-308, 1999.
Michael Karas, Doris Bachmann, Ute Bahr, and Franz Hillenkamp.
Matrix-Assisted Ultraviolet Laser Desorption of Non-Volatile
Compounds.
International Journal of Mass Spectrometry and Ion Processes,
78:53-68, 1987.
Michael Karas and Franz Hillenkamp.
Laser Desorption Ionization of Proteins with Molecular Masses
Exceeding 10000 Daltons.
Analytical Chemistry, 60(20):2299-2301, 1988.
Gunter Kuhnle.
Nutzung der massenspektrometrie zum aktivitätsnachweis von
ribonukleasen gegnüber kurz- und mittelkettigen substraten.
Master's thesis, Universität Leipzig, 1998.
Gunter Kuhnle, Dietrich Haferburg, Marlis Grunow, and Ulrich Hahn.
Mass spectrometric analysis of enzymatic reactions.
In Proceedings of the 23 Annual Meeting, page 97.
British Mass Spectrometry Society, 1998.
Gunter Kuhnle, Dietrich Haferburg, Marlis Grunow, and Ulrich Hahn.
Mass spectrometry with a new nanoes-like source.
In Proceedings of the 24 Annual Meeting. British Mass
Spectrometry Society, 1999.
Gunter Kuhnle, Hagen Schroeter, Dietrich Haferburg, Marlis Grunow, Catherine
Rice-Evans, and Ulrich Hahn.
Online reaction monitoring using nano-es.
In 15th IMSC, Barcelona, August 2000. International Mass
Spectrometry Society.
Gunter Kuhnle, Jeremy P. E. Spencer, George Chowrimootoo, Hagen Schroeter,
Edward S. Debnam, S. Kaila S. Srai, Catherine Rice-Evans, and Ulrich Hahn.
Resveratrol is absorbed in the small intestine as resveratrol
glucuronide.
Biochemical and Biophysical Research Communications,
272(1):212-217, 2000.
Gunter Kuhnle, Jeremy P. E. Spencer, Hagen Schroeter, Baskar Shenoy, Edward S.
Debnam, S. Kaila S. Srai, Catherine Rice-Evans, and Ulrich Hahn.
Epicatechin and catechin are o-methylated and glucuronidated in the
small intestine.
Biochemical and Biophysical Research Communication,
277(2):507-512, 2000.
Gunter G. Kuhnle, Dietrich Haferburg, Marlis Grunow, Dietmar Hirsch, and Ulrich
Hahn.
Nano-electrospray with a modified commercial ionspray source.
Rapid Communications in Mass Spectrometry, 14(14):1307-1308,
2000.
Daniel Lafitte, Albert J. R. Heck, Tessa J. Hill, Kornelia Jumel, Stephen E.
Harding, and Peter J. Derrick.
Evidence of noncovalent dimerization of calmodulin.
European Journal of Biochemistry, 261(1):337-344, 1999.
Philipp Eduard Anton Lenard.
Über die Wasserfallelektrizität und über die
Oberflächenbeschaffenheit der Flüssigkeiten.
Annalen der Physik, 47(4):463-524, 1915.
Andrea Lenz, Frank Cordes, Udo Heinemann, and Wolfram Saenger.
Evidence for a Substrate-binding Subsite in Ribonuclease T1.
Journal of Biological Chemistry, 266(12):7661-7667, 1991.
Yingfu Li and Ronald R. Breaker.
Kinetics of rna degradation by specific base catalysis of
transesterification involving the 2'-hydroxyl group.
Journal of the American Chemical Society, 121(23):5364-5372,
1999.
Boris Aleksandrovich Mamyrin, V. I. Karataev, D. V. Shmikk, and V. A. Zagulin.
The mass-reflectron, a new nonmagnetic time-of-flight mass
spectrometer with high resolution.
Sov. Phys.-JETP, 37(1):45-48, 1973.
Original: Zh. Eksp. Teor. Fiz. 64, 82-89.
José Martinez-Oyanedel, Hui-Woog Choe, Udo Heinemann, and Wolfram Saenger.
Ribonuclease t1 with free recognition and catalytic site: crystal
structure analysis at 1.5 a resolution.
Journal of Molecular Biology, 222(2):335-352, 1991.
Katsuhiko Nohga, Ramachandra R. Reddy, and Harris Busch.
Comparison of rnase t1 fingerprints of u1, u2, and u3 small nuclear
rna's of hela cells, human normal fibroblasts, and novikoff hepatoma cells.
Cancer Research, 41(6):2215-2220, June 1981.
Mikko Oivanen, Satu Kuusela, and Harri Lönneberg.
Kinetics and mechanisms for the cleavage and isomerization of the
phosphodiester bonds of rna by brønsted acids and bases.
Chemical Reviews, 98(3):961-990, 1998.
Harry L. Osterman and Frederick G. Walz, Jr.
Subsites and catalytic mechanism of ribonuclease T1: kinetic studies
using GpA, GpC, GpG, and GpU as substrates.
Biochemistry, 17(20):4124-4130, 1978.
Harry L. Osterman and Frederick G. Walz, Jr.
Subsite interactions and ribonuclease t catalysis: Kinetic
studies with apgpc and apgpu.
Biochemistry, 18(10):1984-1988, 1979.
Petr Pancoska, Heinz Fabian, Gorm Yoder, Vladimir Baumruk, and Timothy A.
Keiderling.
Protein structural segments and their interconnections derived from
optical spectra: Thermal unfolding of ribonuclease t as an example.
Biochemistry, 35(40):13094-13106, 1996.
Wolfgang Paul, Hans-Peter Reinhard, and U. von Zahn.
Der elektrische Massenfilter als Massenspektrometer und
Isotopentrenner.
Zeitschrift für Physik, 152(2):143-182, 1958.
Stefanie Pfeiffer, Yasmin Karimi-Nejad, and Heinz Ruterjans.
Limits of nmr structure determination using variable target function
calculations: ribonuclease t1, a case study.
Journal of Molecular Biology, 266(2):400-423, 1997.
Lenore M. Polo and Patrick A. Limbach.
Matrix-assisted laser desorption/ionization time-of-flight mass
spectrometry for the analysis of rnase h cleavage products.
Journal of Mass Spectrometry, 33(12):1226-1231, 1998.
Maarten A. Posthumus, Piet G. Kistemaker, and Henk L. C. Meuzelaar.
Laser desorption-mass spectrometry of polar nonvolatile bio-organic
molecules.
Analytical Chemistry, 50:985-991, 1978.
Lord John William Strutt Rayleigh.
On the Equilibrium of Liquid Conducting Masses charged with
Electricity.
Philosophical Magazine and School of Science,
14(LXXXVII):184-186, 1882.
Andreas R. Rechner, Jeremy P. E. Spencer, Gunter Kuhnle, Ulrich Hahn, and
Catherine A. Rice-Evans.
Novel biomarkers of the metabolism of caffeic acid derivatives in
vivo.
Free Radical Biology & Medicine, 30(11):1213-1222, 2001.
Franz W. Röllgen, Hubert Nehring, and Ulrich Giessmann.
Mechanisms of field induced desolvation of ions from liquds.
In A. Hedin, B. U. R. Sundqvist, and A. Benninghovem, editors, Ion Formation from Organic Solids (IFOS V); Proceedings of the Fifth
International Conference, Lövanger, Sweden, pages 155-160, June 1989.
Abraham H. Savitzky and Marcel J. E. Golay.
moothing and differentiation of data by simplified least squares
procedures.
Analytical Chemistry, 36(8):1627-1639, 1964.
Franz Xaver Schmid, Christian Frech, Christian Scholz, and Stefan Walter.
Catalyzed and assisted protein folding of ribonuclease t1.
Biological Chemistry, 377(7-8):417-424, 1996.
Jocelyn C. Schulz, Christopher A. Hack, and W. Henry Benner.
Mass determination of megadalton-dna electrospray ions using charge
detection mass spectrometry.
Journal of the American Society for Mass Spectrometry,
9(4):305-313, 1998.
András Simoncsits, George G. Brownlee, R. S. Brown, J. R. Rubin, and
H. Guilley.
New rapid gel sequencing method for rna.
Nature, 269(5631):833-836, October 1977.
Jeremy P. E. Spencer, Hagen Schroeter, Gunter Kuhnle, S. Kaila S. Srai, Rex M.
Tyrrell, Ulrich Hahn, and Catherine Rice-Evans.
Epicatechin and its in vivo metabolite, 3'-o-methyl
epicatechin, protect human fibroblasts from oxidative stress-induced cell
death involving caspase-3 activation.
Biochemical Journal, 354:493-500, 2001.
Jan Steyaert.
A decade of protein engineering on ribonuclease t1 - atomic
dissection of the enzume-substrate interactions.
European Journal of Biochemistry, 247(1):1-11, 1997.
Jan Steyaert and Yves Engleborghs.
A two-binding-site kinetic model for ribonuclease-T1-catalysed
transesterification of dinucleotide phosphate substrates.
European Journal of Biochemistry, 233:140-144, 1995.
Jan Steyaert, Lode Wyns, and Patrick Stanssens.
Subsite Interactions of Ribonuclease T1: Viscosity Effects Indicate
That the Rate-Limiting Step of GpN Transesterification Depends on the Nature
of N.
Biochemistry, 30:8661-8665, 1991.
Kenji Takahashi.
The structure and function of ribonuclease t1. xii. further studies
on rose bengal-catalyzed photooxidation of ribonuclease t1-identification of
a critical histidine residue.
Journal of Biochemistry (Tokyo), 69(2):331-338, February 1971.
Kenji Takahashi.
A revision and confirmation of the amino acid sequence of
ribonuclease t1.
Journal of Biochemistry (Tokyo), 98(3):815-817, September
1985.
Kenji Takahashi and S. Moore.
The enzymes.
In Paul D. Boyer, Henry Lardy, and Karl Myrbäck, editors, Nucleic Acids, volume XV, pages 435-468. Academic Press, New York, USA,
1982.
Koichi Tanaka, Yutaka Ido, Satoshi Akita, Yoshikazu Yoshida, and Tamio Yoshida.
.
In Japan-China Joint Symposiumon Mass Spectrometry, page 219.
Japanese Society for Medical Mass Spectrometry, 1987.
Frederick G. Walz, Jr.
Upstream subsite interactions for oligonucleotide binding with
ribonuclease T1.
Biochimica et Biophysica Acta, 1350:183-188, 1997.
Frederick G. Walz, Jr., Harry L. Ostermann, and Charissa Libertin.
Base-Group Specifity at the Primary Recognition Site of
Ribonuclease T1 for Minimal RNA Substrates.
Archives of Biochemistry and Biophysics, 195(1):95-102, 1979.
Frederick G. Walz, Jr. and Barry Terenna.
Substite Interactions of Ribonuclease T1: Binding Studies of Dimeric
Substrate Analogues.
Biochemistry, 15(13):2837-2842, 1976.
Craig M. Whitehouse, Robert N. Dreyer, Masamichi Yashamita, and John B. Fenn.
Electrospray Interface for Liquid Chromatographs and Mass
Spectrometers.
Analytical Chemistry, 57(3):675-679, 1985.
W. C. Wiley and I. H. McLaren.
Time-of-Flight Mass Spectrometer with Improved Resolution.
The Review of Scientific Instruments, 26(12):1150-1157, 12
1955.
Matthias Wilm and Matthias Mann.
Electrospray and taylor-cone theory, dole's beam of macromolecules at
last?
International Journal of Mass Spectrometry and Ion Processes,
136(2-3):167-180, 1994.
Konrad Wörner, Karlheinz Faulstich, and Joachim W. Engels.
Recent Developments in Mass Spectrometry: RNA-Sequencing.
Nucleotides & Nucleotides, 16(5 & 6):573-577, 1997.
Kuang Jen Wu, Thomas A. Shaler, and Christopher H. Becker.
Time-Of-Flight Mass Spectrometry of Underivatized Single-Stranded
DNA Oligomers by Matrix-Assisted Laser Desorption.
Analytical Chemistry, 66(10):1637-1645, 1994.
Masamichi Yamashita and John B. Fenn.
Electrospray Ion Source. Another Variation on the Free-Jet Theme.
Journal of Physical Chemistry, 88:4451-4459, 1984.
Ingrid Zegers, Remy Loris, Gillis Dehollander, Abdel Fattah Haikal, Freddy
Poortmans, Jan Steyaert, and Lode Wyns.
Hydrolysis of a slow cyclic thiophosphate substrate of rnase t1
analyzed by time-resolved crystallography.
Nature Structural Biology, 5(4):280-283, April 1998.